Methotrexate-associated Lymphoproliferative Disease with Multiple Pulmonary Nodules in a Patient with Rheumatoid Arthritis.

Abstract

Patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) sometimes develop lymphoproliferative disease (LPD). MTX-associated LPD can affect nodal or extranodal sites, including the gastrointestinal tract, skin, lungs, kidneys and soft tissues, at almost equal frequency. However, it is very rare for MTX-associated LPD to manifest as multiple nodules in the lungs. We herein report the case of a RA patient who developed MTX-associated LPD with multiple pulmonary nodules during a 5-year course of MTX therapy.

• Authors: Koichiro Suemori, Hitoshi Hasegawa, Jun Ishizaki, Takuya Matsumoto, Sachiko Onishi, Eiji Sada, Atsuro Sugita, Masaki Yasukawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 11 Pg. 1421-5 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 26028000 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Methotrexate

Topics

• Aged
• Arthritis, Rheumatoid (drug therapy)
• Female
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Lymphoproliferative Disorders (chemically induced)
• Methotrexate (adverse effects, therapeutic use)
• Multiple Pulmonary Nodules (chemically induced)