In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H.

Abstract

Angiogenesis is the process of new vessel formation from pre-existing blood vasculature and is critical for continuous tumor growth. We previously reported that an ethanolic extract of Gleditsia sinensis thorns (EEGS) and its active constituent, cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. In the present study, EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. We repeatedly observed the anti-tumor and anti-metastatic effects of EEGS in representative animal models. These results suggest that EEGS and its active constituent, cytochalasin H, are potential candidates for the development of anti-angiogenic cancer drugs.

• Authors: Jin-Mu Yi, Jinhee Kim, Jong-Shik Park, Jun Lee, You Jin Lee, Jin Tae Hong, Ok-Sun Bang, No Soo Kim
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 38 Issue 6 Pg. 909-12 ( 2015) ISSN: 1347-5215 [Electronic] Japan
• PMID: 26027832 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents, Phytogenic
• Cytochalasins
• Plant Extracts
• cytochalasin H

Topics

• Angiogenesis Inhibitors (pharmacology, therapeutic use)
• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use)
• Cell Line, Tumor
• Chick Embryo
• Cytochalasins (pharmacology, therapeutic use)
• Gleditsia (chemistry)
• Humans
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neovascularization, Pathologic (drug therapy)
• Phytotherapy
• Plant Epidermis
• Plant Extracts (pharmacology, therapeutic use)