Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Immunohistochemistry, array comparative genomic hybridization (aCGH) and genetic analyses were performed. RESULTS: Immunohistochemistry confirmed constitutive activation of mTOR. aCGH revealed a hyperdiploid karyotype affecting large regions of the genome. Next-generation sequencing did not reveal any tumor-specific mutations in mTOR-related genes. CONCLUSION: Our results show the complexity of determining causal genetic alterations that can predict responsiveness to mTOR inhibition, even for a tumor with a complete remission to this specific treatment.
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Authors | Fleur Weeber, Marco J Koudijs, Marlous Hoogstraat, Nicolle J M Besselink, Stef VAN Lieshout, Isaac J Nijman, Edwin Cuppen, G Johan Offerhaus, Emile E Voest |
Journal | Anticancer research
(Anticancer Res)
Vol. 35
Issue 6
Pg. 3399-403
(Jun 2015)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 26026101
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Everolimus
- MTOR protein, human
- TOR Serine-Threonine Kinases
- Sirolimus
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Topics |
- Biomarkers, Tumor
- Comparative Genomic Hybridization
- Everolimus
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Targeted Therapy
- Perivascular Epithelioid Cell Neoplasms
(genetics, pathology)
- Remission Induction
- Signal Transduction
(drug effects)
- Sirolimus
(administration & dosage, analogs & derivatives)
- TOR Serine-Threonine Kinases
(antagonists & inhibitors, genetics)
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