Abstract |
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4-8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow.
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Authors | Tadaaki Watanabe, Emi Inoue, Hiroshi Mori, Yoshiaki Osawa, Katsunori Okazaki |
Journal | Archives of virology
(Arch Virol)
Vol. 160
Issue 8
Pg. 2087-91
(Aug 2015)
ISSN: 1432-8798 [Electronic] Austria |
PMID | 26025155
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Cattle
- Enzootic Bovine Leukosis
(virology)
- Gene Products, pol
(genetics, metabolism)
- Leukemia Virus, Bovine
(enzymology, genetics, physiology)
- Mutation
- Superinfection
- Virus Replication
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