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Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene.

Abstract
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4-8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow.
AuthorsTadaaki Watanabe, Emi Inoue, Hiroshi Mori, Yoshiaki Osawa, Katsunori Okazaki
JournalArchives of virology (Arch Virol) Vol. 160 Issue 8 Pg. 2087-91 (Aug 2015) ISSN: 1432-8798 [Electronic] Austria
PMID26025155 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gene Products, pol
Topics
  • Animals
  • Cattle
  • Enzootic Bovine Leukosis (virology)
  • Gene Products, pol (genetics, metabolism)
  • Leukemia Virus, Bovine (enzymology, genetics, physiology)
  • Mutation
  • Superinfection
  • Virus Replication

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