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Intracystic interferon-α treatment leads to neurotoxicity in craniopharyngioma: case report.

Abstract
Craniopharyngioma is a benign, cystic suprasellar tumor that can be treated with intracystic chemotherapy. Interferon-α (IFN-α) has been gaining popularity as an intracystic treatment for craniopharyngioma because of its efficacy and supposed benign neurotoxicity profile. In this case report the authors describe a patient who, while receiving intracystic IFN-α, suffered a neurological event, which was believed to be related to drug leakage outside the cyst. This is the first report of a focal neurological deficit potentially attributable to intracystic IFN-α therapy, highlighting the fact that IFN-α may have neurotoxic effects on the central nervous system. Given this case and the results of a literature review, the authors suggest that a positive leak test is a relative contraindication to intracystic IFN-α treatment.
AuthorsJulia Sharma, Christopher M Bonfield, Ash Singhal, Juliette Hukin, Paul Steinbok
JournalJournal of neurosurgery. Pediatrics (J Neurosurg Pediatr) Vol. 16 Issue 3 Pg. 301-4 (Sep 2015) ISSN: 1933-0715 [Electronic] United States
PMID26023721 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Interferon-alpha
  • Bleomycin
Topics
  • Antineoplastic Agents (administration & dosage, adverse effects)
  • Aphasia, Broca (chemically induced)
  • Bleomycin (administration & dosage, adverse effects)
  • Brain Edema (chemically induced, complications)
  • Child
  • Craniopharyngioma (diagnosis, drug therapy, surgery)
  • Female
  • Humans
  • Injections, Intralesional
  • Interferon-alpha (administration & dosage, adverse effects)
  • Magnetic Resonance Imaging
  • Pituitary Neoplasms (diagnosis, drug therapy, surgery)
  • Seizures (chemically induced)
  • Tomography, X-Ray Computed

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