Abstract |
Craniopharyngioma is a benign, cystic suprasellar tumor that can be treated with intracystic chemotherapy. Interferon-α (IFN-α) has been gaining popularity as an intracystic treatment for craniopharyngioma because of its efficacy and supposed benign neurotoxicity profile. In this case report the authors describe a patient who, while receiving intracystic IFN-α, suffered a neurological event, which was believed to be related to drug leakage outside the cyst. This is the first report of a focal neurological deficit potentially attributable to intracystic IFN-α therapy, highlighting the fact that IFN-α may have neurotoxic effects on the central nervous system. Given this case and the results of a literature review, the authors suggest that a positive leak test is a relative contraindication to intracystic IFN-α treatment.
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Authors | Julia Sharma, Christopher M Bonfield, Ash Singhal, Juliette Hukin, Paul Steinbok |
Journal | Journal of neurosurgery. Pediatrics
(J Neurosurg Pediatr)
Vol. 16
Issue 3
Pg. 301-4
(Sep 2015)
ISSN: 1933-0715 [Electronic] United States |
PMID | 26023721
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Interferon-alpha
- Bleomycin
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Topics |
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Aphasia, Broca
(chemically induced)
- Bleomycin
(administration & dosage, adverse effects)
- Brain Edema
(chemically induced, complications)
- Child
- Craniopharyngioma
(diagnosis, drug therapy, surgery)
- Female
- Humans
- Injections, Intralesional
- Interferon-alpha
(administration & dosage, adverse effects)
- Magnetic Resonance Imaging
- Pituitary Neoplasms
(diagnosis, drug therapy, surgery)
- Seizures
(chemically induced)
- Tomography, X-Ray Computed
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