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Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment.

Abstract
Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD.
AuthorsSwapnil Rane, Seema Rana, Chetan Mudrabettu, Vivekananda Jha, Kusum Joshi
JournalClinical kidney journal (Clin Kidney J) Vol. 5 Issue 5 Pg. 383-9 (Oct 2012) ISSN: 2048-8505 [Print] England
PMID26019812 (Publication Type: Journal Article)

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