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Fatal phenytoin-related toxic epidermal necrolysis: case report.

Abstract
Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head injury. The typical course and current management of toxic epidermal necrolysis are reviewed, as are the indications for the prophylaxis of posttraumatic epilepsy.
AuthorsD F Kelly, D G Hope
JournalNeurosurgery (Neurosurgery) Vol. 25 Issue 6 Pg. 976-8 (Dec 1989) ISSN: 0148-396X [Print] United States
PMID2601830 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Phenytoin
Topics
  • Humans
  • Male
  • Middle Aged
  • Phenytoin (toxicity)
  • Stevens-Johnson Syndrome (pathology)

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