Onabotulinum toxin A (Botox) for chronic migraine treatment: an Italian experience.

Abstract

Chronic migraine is a common and debilitating headache syndrome. Botulinum neurotoxin, a potent toxin produced by the anaerobic bacterium clostridium botulinum, used largely for treatment of disorders associated with increased muscle tone and hyperhidrosis, is used for patients suffering from chronic migraine. In this study, a group of patients suffering from chronic migraine with medication overuse was treated with onabotulinum toxin A (Botox) to verify its efficacy for chronic migraine. The results confirmed the efficacy of onabotulinum toxin A (Botox) when used at the dosage of 155 UI according to the PREEMPT protocol. Although these results are preliminary, they led to intense efforts to evaluate the analgesic properties of onabotulinum toxin A (Botox) and to assess its use in clinical practice, in particular in migraine field.

• Authors: L Grazzi, S Usai
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 36 Suppl 1 Pg. 33-5 (May 2015) ISSN: 1590-3478 [Electronic] Italy
• PMID: 26017508 (Publication Type: Multicenter Study, News)

Chemical References

• Acetylcholine Release Inhibitors
• Botulinum Toxins, Type A

Topics

• Acetylcholine Release Inhibitors (therapeutic use)
• Botulinum Toxins, Type A (therapeutic use)
• Chronic Disease
• Female
• Follow-Up Studies
• Humans
• Italy
• Male
• Migraine Disorders (drug therapy, metabolism, psychology)
• Quality of Life
• Surveys and Questionnaires