Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The majority of recent studies have evaluated soluble mesothelin in effusions in a diagnostic setting for mesothelioma. However, at high specificity, the sensitivity of the assay is limited to approximately 60% at the time of diagnosis. There is considerable research effort directed toward the identification of new markers for mesothelioma through a variety of genomic, proteomic and immunomic based platforms. One of the few new biomarkers to be identified through a biomarker discovery pipeline and evaluated in pleural effusions is fibulin-3. Preliminary results on the diagnostic accuracy of fibulin-3 have been inconsistent. SUMMARY:
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Authors | Jenette Creaney, Ian M Dick, Bruce W Robinson |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 21
Issue 4
Pg. 352-6
(Jul 2015)
ISSN: 1531-6971 [Electronic] United States |
PMID | 26016578
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Biomarkers, Tumor
- EFEMP1 protein, human
- Extracellular Matrix Proteins
- GPI-Linked Proteins
- Mesothelin
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Topics |
- Biomarkers, Tumor
- Diagnosis, Differential
- Extracellular Matrix Proteins
- GPI-Linked Proteins
- Humans
- Lung Neoplasms
- Mesothelin
- Mesothelioma
- Mesothelioma, Malignant
- Pleural Effusion
(diagnosis)
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