[Polysuccinimide exhibited antitumor activity in the experiment].

Abstract

Antitumor activity of the novel for oncology compound, such as polysuccinimide, against some of experimental tumor models (Lewis lung carcinoma, Acatol adenocarcinoma, Ca-755 adenocarcinoma) has been established. This drug induced 60-80% tumor growth inhibition of these murine solid tumor strains. Polysuccinimide is also effective (60%) against development of metastatic process in lung (Lewis lung carcinoma). Polysuccinimide causes no changes in pH level in tumor tissue (P-388 leukemia, Acatol adenocarcinoma). This agent may be recommended for further profound preclinical study.

• Authors: L A Ostrovskaya, D B Korman, S D Varfolomeev, V A Goldberg, M M Fomina, N V Bluhterova, V A Rikova
• Journal: Biofizika (Biofizika) 2015 Mar-Apr Vol. 60 Issue 2 Pg. 371-6 ISSN: 0006-3029 [Print] Russia (Federation)
• PMID: 26016035 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Peptides
• poly-DL-succinimide
• Aspartic Acid

Topics

• Adenocarcinoma (drug therapy, pathology)
• Animals
• Antineoplastic Agents (administration & dosage)
• Aspartic Acid (administration & dosage, analogs & derivatives, chemical synthesis)
• Carcinoma, Lewis Lung (drug therapy, pathology)
• Humans
• Mice
• Peptides (administration & dosage, chemical synthesis)