Insights into cardio-oncology: Polypharmacology of quinazoline-based α1-adrenoceptor antagonists.

Abstract

New uses of cardiovascular drugs with proven experience are emerging, including for treating cancer. Quinazoline is a compound made up of two fused six member simple aromatic rings, benzene and pyrimidine rings, with several biological effects. Cardiologists first used quinazoline-based α1-adrenoceptor antagonists prazosin, doxazosin, and terazosin; currently available data support their use as safe, well tolerated, and effective add-on therapy in uncontrolled hypertension with additional favourable metabolic effects. Recent findings highlight the anticancer effects of quinazoline-based α1-adrenoceptor antagonists, indicating that they may have a significant role in uncontrolled hypertensive cancer patients without signs of ischemia.

• Authors: Salvatore Patanè
• Journal: World journal of cardiology (World J Cardiol) Vol. 7 Issue 5 Pg. 238-42 (May 26 2015) ISSN: 1949-8462 [Print] United States
• PMID: 26015856 (Publication Type: Journal Article, Review)