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Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats.

AbstractBACKGROUND:
Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity.
OBJECTIVE:
The present study was carried out to evaluate the antioxidant activity of ethanolic extract of Tinospora cordifolia (EETC) in N-nitrosodiethylamine (DEN) induced liver cancer in male Wister albino rats.
MATERIALS AND METHODS:
The antioxidant activity was assessed by the levels of lipid peroxidation (LPO), enzymic and nonenzymic antioxidants.
RESULT:
A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals.
CONCLUSIONS:
The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal.
AuthorsR Jayaprakash, V Ramesh, M P Sridhar, C Sasikala
JournalJournal of pharmacy & bioallied sciences (J Pharm Bioallied Sci) Vol. 7 Issue Suppl 1 Pg. S40-5 (Apr 2015) ISSN: 0976-4879 [Print] India
PMID26015745 (Publication Type: Journal Article)

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