Abstract | BACKGROUND:
Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity. OBJECTIVE: MATERIALS AND METHODS: RESULT: A significant levels of LPO was increased as the enzymic and nonenzymic antioxidants values were decreased in liver cancer bearing animals. CONCLUSIONS: The administration of EETC to cancer bearing animals reverted the LPO levels, enzymic and nonenzymic antioxidants to near normal.
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Authors | R Jayaprakash, V Ramesh, M P Sridhar, C Sasikala |
Journal | Journal of pharmacy & bioallied sciences
(J Pharm Bioallied Sci)
Vol. 7
Issue Suppl 1
Pg. S40-5
(Apr 2015)
ISSN: 0976-4879 [Print] India |
PMID | 26015745
(Publication Type: Journal Article)
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