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In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.

Abstract
We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
AuthorsDébora Nunes Mario, Josep Guarro, Janio Morais Santurio, Sydney Hartz Alves, Javier Capilla
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 8 Pg. 5018-21 (Aug 2015) ISSN: 1098-6596 [Electronic] United States
PMID26014930 (Publication Type: Journal Article)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Chemical References
  • Antifungal Agents
  • Triazoles
  • posaconazole
  • Amphotericin B
Topics
  • Amphotericin B (therapeutic use)
  • Animals
  • Antifungal Agents (therapeutic use)
  • Drug Resistance, Multiple, Fungal
  • Drug Therapy, Combination
  • Mice
  • Microbial Sensitivity Tests
  • Sporothrix (drug effects, pathogenicity)
  • Sporotrichosis (drug therapy)
  • Triazoles (therapeutic use)

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