Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.

Abstract

Phagocytosis of malaria pigment (hemozoin) induces increased activity of matrix metalloproteinase (MMP)-9, an endopeptidase involved in cytokine regulation. In this study, we examined whether a common functional MMP-9 promoter polymorphism (rs3918242) affects Plasmodium falciparum infection in pregnancy. Eighteen percent of Ghanaian primiparae carried the minor T allele. It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. The results indicate that a common MMP-9 polymorphism protects against placental malaria indicating that this endopeptidase is involved in susceptibility to P. falciparum.

• Authors: Thittayil Suresh Apoorv, Phanithi Prakash Babu, Stefanie Meese, Prabhanjan P Gai, George Bedu-Addo, Frank P Mockenhaupt
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 93 Issue 1 Pg. 186-8 (Jul 2015) ISSN: 1476-1645 [Electronic] United States
• PMID: 26013370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The American Society of Tropical Medicine and Hygiene.

Chemical References

• MMP9 protein, human
• Matrix Metalloproteinase 9

Topics

• Adolescent
• Adult
• Female
• Ghana
• Humans
• Malaria, Falciparum (genetics)
• Matrix Metalloproteinase 9 (genetics)
• Placenta (parasitology)
• Placenta Diseases (genetics)
• Polymorphism, Single Nucleotide
• Pregnancy
• Pregnancy Complications, Parasitic (genetics)
• Protective Factors
• Young Adult