HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Long-term course of 6 boys with congenital nephrogenic diabetes insipidus].

Abstract
From 1975-1986 6 boys with congenital nephrogenic diabetes insipidus were diagnosed at the age of 3 months to 10 years. Symptoms appeared within the first few weeks of life. The diagnosis was confirmed by polyuria, low urinary osmolality (97-225 mosm/kg H20), hypernatraemia (max. 171 mmol/l) and the missing response to vasopressin. The treatment was variable; 4 boys received only hydrochlorothiazide (2-2.5 mg/kg/d) which lead to a reduction of the daily urinary volume of 26-44%. Hyperelectrolytaemia disappeared and a normal thriving could be achieved. Later an additional treatment with indomethacin (2 mg/kg/d) was necessary in 3 boys because of an increase of polyuria; there was a further reduction of the daily urinary volume of 50-60%. The combination of hydrochlorothiazide and indomethacin in the treatment of the congenital nephrogenic diabetes insipidus was well tolerated and seems to be--especially during the first few years of life--a necessary and effective treatment which allows a normal thriving and psychointellectual development.
AuthorsR Kaulitz, J Brodehl
JournalKlinische Padiatrie (Klin Padiatr) 1989 Nov-Dec Vol. 201 Issue 6 Pg. 425-30 ISSN: 0300-8630 [Print] Germany
Vernacular TitleLangfristige Verläufe von 6 Jungen mit kongenitalem nephrogenem Diabetes insipidus.
PMID2601280 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Hydrochlorothiazide
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Diabetes Insipidus (drug therapy, genetics)
  • Follow-Up Studies
  • Humans
  • Hydrochlorothiazide (therapeutic use)
  • Infant
  • Kidney Concentrating Ability (drug effects)
  • Male
  • Pedigree
  • Water-Electrolyte Balance (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: