Abstract |
From 1975-1986 6 boys with congenital nephrogenic diabetes insipidus were diagnosed at the age of 3 months to 10 years. Symptoms appeared within the first few weeks of life. The diagnosis was confirmed by polyuria, low urinary osmolality (97-225 mosm/kg H20), hypernatraemia (max. 171 mmol/l) and the missing response to vasopressin. The treatment was variable; 4 boys received only hydrochlorothiazide (2-2.5 mg/kg/d) which lead to a reduction of the daily urinary volume of 26-44%. Hyperelectrolytaemia disappeared and a normal thriving could be achieved. Later an additional treatment with indomethacin (2 mg/kg/d) was necessary in 3 boys because of an increase of polyuria; there was a further reduction of the daily urinary volume of 50-60%. The combination of hydrochlorothiazide and indomethacin in the treatment of the congenital nephrogenic diabetes insipidus was well tolerated and seems to be--especially during the first few years of life--a necessary and effective treatment which allows a normal thriving and psychointellectual development.
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Authors | R Kaulitz, J Brodehl |
Journal | Klinische Padiatrie
(Klin Padiatr)
1989 Nov-Dec
Vol. 201
Issue 6
Pg. 425-30
ISSN: 0300-8630 [Print] Germany |
Vernacular Title | Langfristige Verläufe von 6 Jungen mit kongenitalem nephrogenem Diabetes insipidus. |
PMID | 2601280
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Child
- Child, Preschool
- Diabetes Insipidus
(drug therapy, genetics)
- Follow-Up Studies
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Infant
- Kidney Concentrating Ability
(drug effects)
- Male
- Pedigree
- Water-Electrolyte Balance
(drug effects)
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