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Beneficial Effects of Supplementation of the Rare Sugar "D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice.

Abstract
A rare sugar, D-allulose (also called D-psicose), has recently been applied as a food supplement in view of controlling diabetes and obesity in Japan. D-allulose has been proven to have unique effects against hyperglycemia and hyperlipidemia in a number of studies using several species of rats and mice. However, the antiobesity effects of D-allulose have not yet been assessed in Lep(ob)/Lep(ob) (ob/ob) mice. Therefore, this study explored the dietary supplemental effects of this sugar in leptin-deficient ob/ob mice. Consequently, the subchronic ingestion of D-allulose in ob/ob mice for 15 wk significantly decreased the body and liver weights, and the loss of body weight was involved in the reduction of the total fat mass, including abdominal visceral fat, and not fat-free body mass, including muscle. Furthermore, D-allulose improved hepatic steatosis, as evaluated using hepatic histological studies and MRI. In the normal mice, none of these parameters were influenced by the single or long-term ingestion of D-allulose. These results indicate that dietary supplementation of D-allulose especially influences postprandial hyperglycemia and obesity-related hepatic steatosis, without exercise therapy or dietary restriction. Therefore, D-allulose may be useful as a supplement for preventing and improving obesity and obesity-related disorders.
AuthorsKouichi Itoh, Shodo Mizuno, Sayuri Hama, Wataru Oshima, Miku Kawamata, Akram Hossain, Yasuhiro Ishihara, Masaaki Tokuda
JournalJournal of food science (J Food Sci) Vol. 80 Issue 7 Pg. H1619-26 (Jul 2015) ISSN: 1750-3841 [Electronic] United States
PMID26012374 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2015 Institute of Food Technologists®
Chemical References
  • Leptin
  • psicose
  • Fructose
Topics
  • 3T3-L1 Cells
  • Adipose Tissue (drug effects, metabolism)
  • Animals
  • Body Composition
  • Body Weight
  • Cell Differentiation (drug effects)
  • Dietary Supplements
  • Fatty Liver (drug therapy)
  • Fructose (administration & dosage)
  • Leptin (deficiency)
  • Liver (drug effects, metabolism)
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Obesity (drug therapy)
  • Organ Size (drug effects)

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