Apoptosis induced by weisiensin B isolated from Rabdosia weisiensis C.Y. Wu in K562.

Abstract

The ent-kaurane diterpenoid weisinensis B shows significant cytotoxicity to human chronic myeloid leukemia K562 cells. It inhibits cell growth at low concentration and kills cells at high concentration. The compound induced cell apoptosis and necrosis mainly associated with G2/M phase cell cycle arrest and the ROS generation is the early event in weisiensin B induced cell apoptosis.

• Authors: Guo-An Liu, Jin-Chun Chang, Xiao-Lu Feng, Lan Ding
• Journal: Die Pharmazie (Pharmazie) Vol. 70 Issue 4 Pg. 263-8 (Apr 2015) ISSN: 0031-7144 [Print] Germany
• PMID: 26012257 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• Reactive Oxygen Species
• weisiensin B

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Cell Cycle (drug effects)
• Cell Death (drug effects)
• Cell Survival (drug effects)
• Diterpenes (pharmacology)
• Humans
• Isodon (chemistry)
• K562 Cells
• Necrosis
• Reactive Oxygen Species (metabolism)