Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

Abstract

Clnk, as a third member of the Blnk/SLP-76 adapter family, is involved in the positive regulation of immunoreceptor signaling. Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells. Therefore, Clnk, as an adaptor protein, may take part in the other cellular processes.

• Authors: Meng Xu, Chengfeng Cai, Xuli Sun, Wanze Chen, Qinxi Li, Huamin Zhou
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 463 Issue 3 Pg. 275-9 (Jul 31 2015) ISSN: 1090-2104 [Electronic] United States
• PMID: 26009488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• Carrier Proteins
• Clnk protein, mouse
• Reactive Oxygen Species
• Tumor Necrosis Factor-alpha
• MLKL protein, mouse
• Protein Kinases
• Receptor-Interacting Protein Serine-Threonine Kinases
• Ripk3 protein, mouse

Topics

• Adaptor Proteins, Signal Transducing
• Animals
• Carrier Proteins (immunology)
• Cell Death
• Cell Line, Tumor
• Fibrosarcoma (immunology, pathology)
• HeLa Cells
• Humans
• Mice
• Necrosis (immunology)
• Protein Kinases (chemistry, immunology)
• Protein Multimerization
• Reactive Oxygen Species (immunology)
• Receptor-Interacting Protein Serine-Threonine Kinases (immunology)
• Signal Transduction
• Tumor Necrosis Factor-alpha (immunology)