Abstract | BACKGROUND/AIMS: MATERIALS AND METHODS: Twenty-five patients with biopsy-proven liver cirrhosis were enrolled in the study. Patients received 1×106 autologous mesenchymal stem cells/kg via a peripheral vein. Biochemical parameters were checked monthly. Periodical radiological screening and liver biopsies before mesenchymal stem cell transplantation were performed after 6 months. Liver specimens were assessed by a pathologist. RESULTS: CONCLUSION: Autologous mesenchymal stem cell transplantation via peripheral vein is safe and feasible. Consecutive liver biopsy examinations suggested that mesenchymal stem cells could not reach the liver in a sufficient amount. Improvement in patients and clearance of HCV RNA may have occurred through immunomodulatory mediators secreted by transplanted mesenchymal stem cells, namely the "endocrine" effect.
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Authors | Murat Kantarcıoğlu, Hakan Demirci, Ferit Avcu, Yıldırım Karslıoğlu, Mustafa Alpaslan Babayiğit, Bülent Karaman, Kadir Öztürk, Hasan Gürel, Meral Akdoğan Kayhan, Sabite Kaçar, Ayhan Kubar, Gürol Öksüzoğlu, Ali Uğur Ural, Sait Bağcı |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 26
Issue 3
Pg. 244-50
(May 2015)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 26006200
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biopsy
- Female
- Hepacivirus
- Hepatitis C
(blood, virology)
- Humans
- Liver
(diagnostic imaging, pathology)
- Liver Cirrhosis
(blood, pathology, surgery)
- Male
- Mesenchymal Stem Cell Transplantation
(methods)
- Middle Aged
- Prospective Studies
- Radiography
- Serum Albumin
(metabolism)
- Severity of Illness Index
- Transplantation, Autologous
- Viral Load
- Young Adult
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