Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood--a comparative ımmunohistochemical study.

Abstract

The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma. Anaplastic lymphoma kinase protein expression in small round cell tumors of childhood is poorly described in the literature. The findings of our study highlight a potential and possible role of targeting ALK in pediatric solid tumors by using ALK immunohistochemistry. Anaplastic lymphoma kinase may also have an oncogenic role in rhabdomyosarcomas and peripheral neuroblastic tumors, and they may possibly be treated with ALK inhibitors. Anaplastic lymphoma kinase expression in Wilms tumors is not reported in the literature, previously. Our study evaluated ALK expression in Wilms tumor samples.

• Authors: Esra Karakuş, Suna Emir, Ayper Kaçar, Resul Karakuş, Hacı Ahmet Demir, Derya Özyörük
• Journal: Annals of diagnostic pathology (Ann Diagn Pathol) Vol. 19 Issue 4 Pg. 239-42 (Aug 2015) ISSN: 1532-8198 [Electronic] United States
• PMID: 26005112 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• ALK protein, human
• Anaplastic Lymphoma Kinase
• Receptor Protein-Tyrosine Kinases

Topics

• Anaplastic Lymphoma Kinase
• Biomarkers, Tumor (biosynthesis, genetics)
• Carcinoma, Small Cell (enzymology, genetics, pathology)
• Child
• Child, Preschool
• Desmoplastic Small Round Cell Tumor (enzymology, genetics, pathology)
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• Male
• Neuroblastoma (enzymology, genetics, pathology)
• Neuroectodermal Tumors, Primitive (enzymology, genetics, pathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (enzymology, genetics, pathology)
• Receptor Protein-Tyrosine Kinases (biosynthesis, genetics)
• Rhabdomyosarcoma (enzymology, genetics, pathology)
• Sarcoma, Ewing (enzymology, genetics, pathology)
• Wilms Tumor (enzymology, genetics, pathology)