Abstract | BACKGROUND: METHODS: We conducted a community-based cross-sectional study including 1083 healthy subjects (323 men and 760 women) in an urban area. We performed multivariate regression analyses to estimate the association between the homeostasis model assessment of insulin resistance (HOMA-IR) values and markers of glycemic control, including glycated haemoglobin (HbA1c), 1,5-anhydroglucitol (1,5-AG), and fasting plasma glucose (FPG) levels, after adjustment for potential confounders. RESULTS: Compared with the lowest tertile of HOMA-IR values, the highest tertile was significantly associated with HbA1c and FPG levels after adjustment for potential confounders, both in men (HbA1c: β = 1.83, P = 0.001; FPG: β = 0.49, P < 0.001) and women (HbA1c: β = 0.82, P = 0.008; FPG: β = 0.39, P < 0.001). The highest tertile of HOMA-IR values was inversely associated with 1,5-AG levels compared with the lowest tertile (β = -18.42, P = 0.009) only in men. CONCLUSIONS:
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Authors | Takumi Hirata, Aya Higashiyama, Yoshimi Kubota, Kunihiro Nishimura, Daisuke Sugiyama, Aya Kadota, Yoko Nishida, Hironori Imano, Tomofumi Nishikawa, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura |
Journal | Journal of epidemiology
(J Epidemiol)
Vol. 25
Issue 6
Pg. 407-14
( 2015)
ISSN: 1349-9092 [Electronic] Japan |
PMID | 26005064
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Blood Glucose
- Glycated Hemoglobin A
- 1,5-anhydroglucitol
- Deoxyglucose
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Topics |
- Aged
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Cross-Sectional Studies
- Deoxyglucose
(blood)
- Diabetes Mellitus
(epidemiology)
- Fasting
(blood)
- Female
- Glycated Hemoglobin
(analysis)
- Homeostasis
- Humans
- Insulin Resistance
- Japan
(epidemiology)
- Male
- Middle Aged
- Models, Biological
- Obesity
(epidemiology)
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