Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort: The multi ethnic study of atherosclerosis.

Abstract

OBJECTIVE:

Prospective studies reporting a positive association of lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity with incident cardiovascular disease (CVD) have included primarily white individuals. We evaluated associations of Lp-PLA2 and first-time cardiovascular events in a healthy multi-ethnic cohort characterized by presence or absence of baseline subclinical atherosclerosis.

METHODS:

Lp-PLA2 mass and activity were measured at baseline in 5456 participants in the Multi-Ethnic Study of Atherosclerosis. Individuals were characterized for presence of baseline subclinical disease (coronary artery calcium score > 0 or carotid intima-media thickness value > 80th percentile) and followed prospectively for development of CVD events (coronary heart disease, ischemic stroke, and cardiovascular death).

RESULTS:

516 incident CVD events occurred over median follow-up of 10.2 years. In adjusted Cox proportional hazards models, each higher standard deviation of both Lp-PLA2 activity and mass was associated with an increased risk of cardiovascular events; hazard ratios (HR; 95% confidence intervals (CI)) 1.12 (1.01-1.26) for Lp-PLA2 activity and 1.10 (1.01-1.21) for mass. Associations did not differ by subclinical disease status (p-value for interaction 0.99 for Lp-PLA2 activity and 0.32 for Lp-PLA2 mass) and there was no confounding by subclinical atherosclerosis measures. Associations of Lp-PLA2 activity but not mass were weaker in Chinese participants but there were relatively few events among Chinese in race-stratified analysis.

CONCLUSION:

In this multi-ethnic cohort, Lp-PLA2 was positively associated with CVD risk, regardless of the presence of coronary artery calcium or a thickened carotid-intimal media.

• Authors: Parveen K Garg, Robyn L McClelland, Nancy S Jenny, Michael H Criqui, Philip Greenland, Robert S Rosenson, David S Siscovick, Neal Jorgensen, Mary Cushman
• Journal: Atherosclerosis (Atherosclerosis) Vol. 241 Issue 1 Pg. 176-82 (Jul 2015) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 26004387 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• 1-Alkyl-2-acetylglycerophosphocholine Esterase
• PLA2G7 protein, human

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood)
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Cardiovascular Diseases (blood, diagnosis, enzymology, ethnology, mortality)
• Carotid Artery Diseases (blood, enzymology, epidemiology)
• Carotid Intima-Media Thickness
• Coronary Angiography
• Coronary Artery Disease (blood, enzymology, epidemiology)
• Female
• Humans
• Incidence
• Linear Models
• Male
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Prospective Studies
• Risk Factors
• Time Factors
• United States (epidemiology)
• Up-Regulation
• Vascular Calcification (blood, enzymology, epidemiology)