Abstract | PURPOSE: MATERIALS AND METHODS: Fifty patients (51 eyes) with uncontrolled secondary neovascular glaucoma and diabetes mellitus were enrolled in the study. All patients with an uncontrolled IOP have been proposed to switch current IOP-lowering therapy to Ganfort®. In case target IOP level was not reached filtration surgery was recommended. Ganfort® administration - once a day in the morning. RESULTS: IOP-lowering has been observed in all patients when switched to Ganfort®. Mean IOP level was almost 3-x lower versus baseline in 72.5% of patients (37 eyes). The patients achieved target IOP of 15-17 mmHg. As a result, no surgical intervention was required. Significant IOP-lowering has been observed in another group of patients (14 eyes, 27.5 %) nevertheless due to glaucoma progression, these patients are still subjected to surgical treatment. CONCLUSION: IOP-lowering fixed combination Ganfort® (Allergan) can be used in patients with secondary neovascular glaucoma and diabetes mellitus as a drug of choice to control the IOP level. Even in cases when target IOP is not achieved, Ganfort® can be administered in pre-operative period and helps to reduce postoperative complications.
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Authors | D V Lipatov, T A Chistyakov, A G Kuzmin, A A Tolkacheva |
Journal | Current diabetes reviews
(Curr Diabetes Rev)
Vol. 11
Issue 4
Pg. 281-4
( 2015)
ISSN: 1875-6417 [Electronic] United Arab Emirates |
PMID | 26004082
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Adrenergic beta-Antagonists
- Amides
- Drug Combinations
- Ganfort
- Cloprostenol
- Timolol
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Topics |
- Adrenergic beta-Antagonists
(adverse effects, therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Amides
(adverse effects, therapeutic use)
- Cloprostenol
(adverse effects, analogs & derivatives, therapeutic use)
- Diabetic Angiopathies
(diagnosis, drug therapy, physiopathology)
- Drug Combinations
- Drug Substitution
- Female
- Glaucoma, Neovascular
(diagnosis, drug therapy, physiopathology)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Timolol
(adverse effects, therapeutic use)
- Treatment Outcome
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