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The fixed combination efficacy assessment in patients with secondary neovascular glaucoma and diabetes mellitus.

AbstractPURPOSE:
To assess IOP-lowering efficacy of bimatoprost/timolol fixed combination (Ganfort®) in patients with diabetes mellitus (DM) and uncontrolled secondary neovascular glaucoma (NG).
MATERIALS AND METHODS:
Fifty patients (51 eyes) with uncontrolled secondary neovascular glaucoma and diabetes mellitus were enrolled in the study. All patients with an uncontrolled IOP have been proposed to switch current IOP-lowering therapy to Ganfort®. In case target IOP level was not reached filtration surgery was recommended. Ganfort® administration - once a day in the morning.
RESULTS:
IOP-lowering has been observed in all patients when switched to Ganfort®. Mean IOP level was almost 3-x lower versus baseline in 72.5% of patients (37 eyes). The patients achieved target IOP of 15-17 mmHg. As a result, no surgical intervention was required. Significant IOP-lowering has been observed in another group of patients (14 eyes, 27.5 %) nevertheless due to glaucoma progression, these patients are still subjected to surgical treatment.
CONCLUSION:
IOP-lowering fixed combination Ganfort® (Allergan) can be used in patients with secondary neovascular glaucoma and diabetes mellitus as a drug of choice to control the IOP level. Even in cases when target IOP is not achieved, Ganfort® can be administered in pre-operative period and helps to reduce postoperative complications.
AuthorsD V Lipatov, T A Chistyakov, A G Kuzmin, A A Tolkacheva
JournalCurrent diabetes reviews (Curr Diabetes Rev) Vol. 11 Issue 4 Pg. 281-4 ( 2015) ISSN: 1875-6417 [Electronic] United Arab Emirates
PMID26004082 (Publication Type: Journal Article, Observational Study)
Chemical References
  • Adrenergic beta-Antagonists
  • Amides
  • Drug Combinations
  • Ganfort
  • Cloprostenol
  • Timolol
Topics
  • Adrenergic beta-Antagonists (adverse effects, therapeutic use)
  • Adult
  • Aged
  • Aged, 80 and over
  • Amides (adverse effects, therapeutic use)
  • Cloprostenol (adverse effects, analogs & derivatives, therapeutic use)
  • Diabetic Angiopathies (diagnosis, drug therapy, physiopathology)
  • Drug Combinations
  • Drug Substitution
  • Female
  • Glaucoma, Neovascular (diagnosis, drug therapy, physiopathology)
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Middle Aged
  • Timolol (adverse effects, therapeutic use)
  • Treatment Outcome

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