The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.

Abstract

The environmental pollutants perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) cause a dramatic reduction in the size of the major adipose tissue depots and a general body weight decrease when they are added to the food of mice. We demonstrate here that this is mainly due to a reduction in food intake; this reduction was not due to food aversion. Remarkably and unexpectedly, a large part of the effect of PFOA/PFOS on food intake was dependent on the presence of the uncoupling protein 1 (UCP1) in the mice. Correspondingly, PFOA/PFOS treatment induced recruitment of brown adipose tissue mitochondria: increased oxidative capacity and increased UCP1-mediated oxygen consumption (thermogenesis). In mice pair-fed to the food intake during PFOA/PFOS treatment in wildtype mice, brown-fat mitochondrial recruitment was also induced. We conclude that we have uncovered the existence of a regulatory component of food intake that is dependent upon brown adipose tissue thermogenic activity. The possible environmental consequences of this novel PFOA/PFOS effect (a possible decreased fitness) are noted, as well as the perspectives of this finding on the general understanding of control of food intake control and its possible extension to combatting obesity.

• Authors: Irina G Shabalina, Tatiana V Kramarova, Charlotte L Mattsson, Natasa Petrovic, Mousumi Rahman Qazi, Robert I Csikasz, Shu-Ching Chang, John Butenhoff, Joseph W DePierre, Barbara Cannon, Jan Nedergaard
• Journal: Toxicological sciences : an official journal of the Society of Toxicology (Toxicol Sci) Vol. 146 Issue 2 Pg. 334-43 (Aug 2015) ISSN: 1096-0929 [Electronic] United States
• PMID: 26001964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• Alkanesulfonic Acids
• Caprylates
• Environmental Pollutants
• Fluorocarbons
• Ion Channels
• Mitochondrial Proteins
• Ucp1 protein, mouse
• Uncoupling Protein 1
• perfluorooctanoic acid
• perfluorooctane sulfonic acid

Topics

• Adipose Tissue, Brown (drug effects, metabolism)
• Alkanesulfonic Acids (toxicity)
• Animals
• Caprylates (toxicity)
• Energy Intake
• Environmental Pollutants (toxicity)
• Fluorocarbons (toxicity)
• Ion Channels (metabolism)
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Mitochondria (drug effects, metabolism)
• Mitochondrial Proteins (metabolism)
• Uncoupling Protein 1
• Up-Regulation (drug effects)