Abstract | BACKGROUND: SETTING: Nationwide cohort study of 13,195 patients, who underwent RYGB 2006-2012 using Danish population-based medical databases. METHODS: Information was obtained on current (redeemed prescription<60 d before surgery), recent (prescription 60-180 d before surgery), or no glucocorticoid use, and postoperative bleeding or infection within 30 days of surgery. We computed risk differences and odds ratios ( ORs) as a measure of relative risk with 95% confidence intervals (95% CIs) for the association between glucocorticoid use and bleeding or infection, adjusting for gender, age, and co-morbidities by logistic regression. RESULTS: Among RYGB patients, 325 (2.5%) were current glucocorticoid users, and 365 (2.8%) were recent users. The risk of bleeding was increased in current users: 2.8% versus 1.6% among nonusers (risk difference: 1.2%, 95% CI: -.6, 3.0) corresponding to an adjusted OR of 1.5 (95% CI: .8, 3.0). For recent users, the adjusted OR for bleeding was 1.2 (95% CI: .5, 2.5). The risk of infection did not differ materially between current (1.8%), recent (1.0%) and nonusers (1.7%), corresponding to an adjusted OR of .9 (95% CI: .4, 2.1) among current versus nonusers. CONCLUSIONS: Current use of glucocorticoids is associated with a slightly increased risk of postoperative bleeding, but not infection, after RYGB. No increased risks were found for recent users.
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Authors | Sigrid Bjerge Gribsholt, Elisabeth Svensson, Reimar Wernich Thomsen, Bjørn Richelsen, Henrik Toft Sørensen |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2015 Nov-Dec
Vol. 11
Issue 6
Pg. 1212-7
ISSN: 1878-7533 [Electronic] United States |
PMID | 26001556
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Denmark
(epidemiology)
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Gastric Bypass
- Glucocorticoids
(administration & dosage, adverse effects)
- Humans
- Incidence
- Male
- Middle Aged
- Obesity, Morbid
(surgery)
- Odds Ratio
- Postoperative Hemorrhage
(chemically induced, epidemiology)
- Preoperative Care
(adverse effects)
- Retrospective Studies
- Risk Assessment
(methods)
- Risk Factors
- Surgical Wound Infection
(chemically induced, epidemiology)
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