Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status.

Abstract

BACKGROUND:

Ribonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit. Expression levels of each subunit have been implicated in prognostic outcomes in several different types of cancers.

EXPERIMENTAL DESIGN:

Immunohistochemistry for RRM1 and RRM2 was performed on a lung cancer tissue microarray (TMA) and analyzed. 326 patients from the microarray were included in this study.

RESULTS:

In non-small cell lung cancer (NSCLC), RRM2 expression was strongly predictive of disease-specific survival in women, non-smokers and former smokers who had quit at least 10 years prior to being diagnosed with lung cancer. Higher expression was associated with worse survival. This was not the case for men, current smokers and those who had stopped smoking for shorter periods of time. RRM1 was not predictive of survival outcomes in any subset of the patient group.

CONCLUSION:

RRM2, but not RRM1, is a useful predictor of survival outcome in certain subsets of NSCLC patients.

• Authors: Vei Mah, Mohammad Alavi, Diana C Márquez-Garbán, Erin L Maresh, Sara R Kim, Steve Horvath, Lora Bagryanova, Sara Huerta-Yepez, David Chia, Richard Pietras, Lee Goodglick
• Journal: PloS one (PLoS One) Vol. 10 Issue 5 Pg. e0127600 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26001082 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Tumor Suppressor Proteins
• ribonucleotide reductase M2
• RRM1 protein, human
• Ribonucleoside Diphosphate Reductase

Topics

• Aged
• Carcinoma, Non-Small-Cell Lung (metabolism, mortality, pathology)
• Female
• Humans
• Lung Neoplasms (metabolism, mortality, pathology)
• Male
• Middle Aged
• Prognosis
• Ribonucleoside Diphosphate Reductase (metabolism)
• Sex Factors
• Smoking
• Survival Rate
• Tumor Suppressor Proteins (metabolism)