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Immunogenicity without Efficacy of an Adenoviral Tuberculosis Vaccine in a Stringent Mouse Model for Immunotherapy during Treatment.

Abstract
To investigate if bacterial persistence during TB drug treatment could be overcome by modulation of host immunity, we adapted a clinically-relevant model developed for the evaluation of new drugs and examined if immunotherapy with two adenoviral vaccines, Ad35-TBS (AERAS-402) and Ad26-TBS, could shorten therapy in mice. Even though immunotherapy resulted in strong splenic IFN-γ responses, no effect on bacterial replication in the lungs was seen. Multiplex assay analysis of lung samples revealed the absence of cytokine augmentation such as IFN-γ, TNF-α and IL-2, suggesting that immunization failed to induce immunity in the lungs. In this model, we show that IFN-γ levels were not associated with protection against disease relapse. The results obtained from our study raise questions regarding the traits of protective TB immunity that are relevant for the development of future immunotherapeutic and post-exposure vaccination strategies.
AuthorsS Anisah Alyahya, Scott T Nolan, Cara M R Smith, William R Bishai, Jerald Sadoff, Gyanu Lamichhane
JournalPloS one (PLoS One) Vol. 10 Issue 5 Pg. e0127907 ( 2015) ISSN: 1932-6203 [Electronic] United States
PMID25996375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Tuberculosis Vaccines
Topics
  • Adenoviridae (genetics)
  • Animals
  • Bacterial Load
  • Cytokines (metabolism)
  • Disease Models, Animal
  • Female
  • Genetic Vectors (genetics)
  • Immunization
  • Immunotherapy
  • Lung (immunology, metabolism, microbiology, pathology)
  • Mice
  • Mycobacterium tuberculosis (immunology)
  • Spleen (immunology)
  • T-Lymphocyte Subsets (immunology, metabolism)
  • Treatment Failure
  • Tuberculosis (immunology, microbiology, therapy)
  • Tuberculosis Vaccines (genetics, immunology)

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