Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse.

Abstract

A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using levallorphan as the internal standard. After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring.

• Authors: P Kintz, P Mangin, A A Lugnier, A J Chaumont
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 37 Issue 5 Pg. 531-2 ( 1989) ISSN: 0031-6970 [Print] Germany
• PMID: 2598995 (Publication Type: Journal Article)

Chemical References

• Illicit Drugs
• Morphine Derivatives
• 6-O-monoacetylmorphine

Topics

• Acetylation
• Gas Chromatography-Mass Spectrometry
• Heroin Dependence (urine)
• Humans
• Illicit Drugs (analysis)
• Morphine Derivatives (urine)