Abstract |
Extrapyramidal signs are neurological dysfunction commonly associated with Wilson's disease (WD). In addition, cognitive dysfunction has been reported in the early stages of WD. In this report, we describe a 49-year-old woman presenting with memory impairments and without Parkinsonian or extrapyramidal signs. She was diagnosed with WD based on the presence of Kayser-Fleischer rings around the irises of her eyes and two ATP7B gene mutations, R778L at exon 8 and A874V at exdyon 11. Serial magnetic resonance imaging analysis and neuropsychological tests showed improvements following treatment with trientine.
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Authors | Eun Joo Chung, Eung Gyu Kim, Sang Jin Kim, Ki-Hwan Ji, Jung Hwa Seo |
Journal | Neurocase
(Neurocase)
Vol. 22
Issue 1
Pg. 40-4
( 2016)
ISSN: 1465-3656 [Electronic] England |
PMID | 25988284
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Chelating Agents
- Trientine
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Topics |
- Brain
(drug effects, pathology)
- Chelating Agents
(pharmacology, therapeutic use)
- Cognition Disorders
(complications, drug therapy, pathology)
- Female
- Hepatolenticular Degeneration
(complications, drug therapy, pathology)
- Humans
- Magnetic Resonance Imaging
- Middle Aged
- Neuropsychological Tests
- Treatment Outcome
- Trientine
(pharmacology, therapeutic use)
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