Abstract |
Studying insecticide resistance in mosquitoes has attracted the attention of many scientists to elucidate the pathways of resistance development and to design novel strategies in order to prevent or minimize the spread and evolution of resistance. Here, we tested the synergistic action of piperonyl butoxide (PBO) and two octopamine receptor (OR) agonists, amitraz (AMZ) and chlordimeform (CDM) on selected novel insecticides to increase their lethal action on the fourth instar larvae of Aedes aegypti L. However, chlorfenapyr was the most toxic insecticide (LC50 = 193, 102, and 48 ng/ml, after 24, 48, and 72 h exposure, respectively) tested. Further, PBO synergized all insecticides and the most toxic combinatorial insecticide was nitenpyram even after 48 and 72 h exposure. In addition, OR agonists significantly synergized most of the selected insecticides especially after 48 and 72 h exposure. The results imply that the synergistic effects of amitraz are a promising approach in increasing the potency of certain insecticides in controlling the dengue vector Ae. aegypti mosquito.
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Authors | Mohamed Ahmed Ibrahim Ahmed, Christoph Franz Adam Vogel |
Journal | Pesticide biochemistry and physiology
(Pestic Biochem Physiol)
Vol. 120
Pg. 51-6
(May 2015)
ISSN: 1095-9939 [Electronic] United States |
PMID | 25987220
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Insecticides
- Pesticide Synergists
- Receptors, Biogenic Amine
- Toluidines
- norsynephrine receptor
- amitraz
- Chlorphenamidine
- Piperonyl Butoxide
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Topics |
- Aedes
(drug effects)
- Animals
- Chlorphenamidine
(pharmacology)
- Dengue
- Insecticides
(toxicity)
- Larva
(drug effects)
- Pesticide Synergists
(pharmacology)
- Piperonyl Butoxide
(pharmacology)
- Receptors, Biogenic Amine
(agonists)
- Toluidines
(pharmacology)
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