Abstract | OBJECTIVE: We investigated the effect of glatiramer acetate (GA) on the modulation of immune cell subpopulations and serum levels of multiple immune/metabolic markers in patients with relapsing-remitting multiple sclerosis (RRMS) to understand whether the treatment with GA could induce a specific change in the immunometabolic asset of patients with RRMS. MATERIAL AND METHODS: RESULTS: Our analysis showed that naïve-to-treatment RRMS patients had a lower number of CD16(+)CD56(+) NK cells, CD19(+) B cells, CD4(+) T cells co-expressing the MHC class II activation marker HLA-DR (CD4(+)DR(+)) and naïve CD4(+)CD45RA(+) T cells in basal conditions. GA treatment induced a specific and significant decrease of circulating CD19(+) B cells. Naïve-to-treatment RRMS patients also showed a significantly higher number of CD4(+) T cells with a memory phenotype (CD4(+)CD45RO(+)) whose peripheral frequency was not affected by GA treatment. These changes over time associated with a higher serum concentration of leptin and lower levels of MPO. GA treatment also reduced significantly the circulating levels of sCD40-L and sTNF-R overtime. CONCLUSIONS: Our data suggest that the clinical outcome of GA treatment is associated with changes in immune cell subpopulations and modulation of specific immunometabolic markers. These data add substantial evidence of the immune modulating effect of GA during RRMS and could be of relevance in understanding the pathogenesis of disease and its follow-up.
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Authors | Pietro B Carrieri, Fortunata Carbone, Francesco Perna, Dario Bruzzese, Claudia La Rocca, Mario Galgani, Silvana Montella, Maria Petracca, Ciro Florio, Giorgia T Maniscalco, Daniele L A Spitaleri, Gerardo Iuliano, Gioacchino Tedeschi, Marida Della Corte, Simona Bonavita, Giuseppe Matarese |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 64
Issue 9
Pg. 1112-21
(Sep 2015)
ISSN: 1532-8600 [Electronic] United States |
PMID | 25986733
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Leptin
- Peptides
- Glatiramer Acetate
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Topics |
- Adult
- Biomarkers
- CD4-Positive T-Lymphocytes
(immunology)
- Female
- Glatiramer Acetate
- Humans
- Leptin
(blood)
- Longitudinal Studies
- Lymphocyte Count
- Male
- Metabolic Syndrome
(metabolism)
- Middle Aged
- Multiple Sclerosis, Relapsing-Remitting
(drug therapy, immunology, metabolism)
- Obesity
(metabolism)
- Peptides
(therapeutic use)
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