Reversible hypopituitarism with pituitary tuberculoma.

Abstract

A 50-year-old woman presented with a headache and nausea. A sellar and suprasellar mass was detected on MRI; the tumor was heterogeneously enhanced with gadolinium, and the pituitary stalk was slightly thickened. Laboratory tests revealed severe growth hormone, luteinizing hormone, follicle-stimulating hormone and thyroid-stimulating hormone deficiencies. A pathological examination of the tumor showed scattered granulomas with central necrosis and Langhans giant cells. Tuberculin skin and QuantiFERON TB-Gold tests (QFT-2G) were positive. Accordingly, we diagnosed the patient with pituitary tuberculoma presenting with pituitary dysfunction. Following treatment with antituberculous drugs, the pituitary hormone function normalized and the pituitary tuberculoma disappeared.

• Authors: Keiji Tanimoto, Ayumi Imbe, Kanako Shishikura, Hisashi Imbe, Tetsuya Hiraiwa, Tomo Miyata, Naokado Ikeda, Toshihiko Kuroiwa, Jungo Terasaki, Toshiaki Hanafusa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 10 Pg. 1247-51 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 25986265 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antitubercular Agents
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Antitubercular Agents (therapeutic use)
• Female
• Follicle Stimulating Hormone (physiology)
• Humans
• Hypopituitarism (etiology)
• Luteinizing Hormone (physiology)
• Magnetic Resonance Imaging
• Middle Aged
• Pituitary Diseases (complications, pathology)
• Pituitary Gland (pathology)
• Tuberculoma (complications, drug therapy, pathology)