Abstract | BACKGROUND AND PURPOSE: The 9-item Wearing-off Questionnaire (WOQ-9) is a useful tool for screening of wearing-off. We performed a validation study of the Japanese version of the WOQ-9 (JWOQ-9) using a cross-sectional design in Japanese Parkinson's disease (PD) patients diagnosed with sporadic PD and treated with levodopa. METHODS: Subjects with severe dementia, uncontrolled psychiatric comorbidities, and previous PD neurosurgery were excluded. The wearing-off phenomenon was detected according to the JWOQ-9, and the results were compared with independent evaluations of wearing-off conducted by PD specialists blinded to the JWOQ-9 results. To validate the JWOQ-9, a sample size of at least 70 patients with wearing-off and 70 patients without wearing-off was required. Therefore, a total of 180 patients (101 patients with wearing-off and 79 patients without wearing-off) were enrolled. RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of the JWOQ-9 were 94.1%, 39.2%, 66.4%, and 83.8%, respectively. Motor symptom questions demonstrated both moderate sensitivity (58.1-87.3%) and specificity (60.4-87.5%). In contrast, non-motor symptom questions demonstrated fair to moderate sensitivity (51.5-64.6%), with high specificity (80.0-94.1%). Like the original WOQ-9, the JWOQ-9 exhibits significant value for detecting possible wearing-off. CONCLUSIONS: The JWOQ-9 is a useful screening tool for detecting wearing-off of both motor and non-motor symptoms.
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Authors | Jiro Fukae, Masa-aki Higuchi, Shosaburo Yanamoto, Kosuke Fukuhara, Jun Tsugawa, Shinji Ouma, Taku Hatano, Asako Yoritaka, Yasuyuki Okuma, Kenichi Kashihara, Nobutaka Hattori, Yoshio Tsuboi |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 134
Pg. 110-5
(Jul 2015)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 25985062
(Publication Type: Journal Article, Validation Study)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Antiparkinson Agents
- Levodopa
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Topics |
- Aged
- Antiparkinson Agents
(therapeutic use)
- Cross-Sectional Studies
- Female
- Humans
- Japan
- Levodopa
(therapeutic use)
- Male
- Middle Aged
- Parkinson Disease
(drug therapy, physiopathology)
- Surveys and Questionnaires
- Translations
- Treatment Outcome
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