Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.

Abstract

AIMS AND BACKGROUND:

Radiotherapy (RT) plays a central role in the management of cancers located in the abdomen and pelvis. However, radiation-induced toxicity remains a major concern for patients receiving RT to the abdominopelvic region. In this context, our study aims to evaluate the use of transforming growth factor (TGF)-β2-enriched formula for amelioration of radiation-induced diarrhea for patients undergoing pelvic RT.

METHODS AND STUDY DESIGN:

Between September 2013 and September 2014, 86 malnourished patients undergoing RT for pelvic cancers who received oral nutritional supplementation with or without TGF-β2-enriched formula were assessed retrospectively in 3 groups. Oral diphenoxylate-atropine tablets were used at onset of diarrhea in all groups. Kruskal-Wallis and chi-square tests were used in the comparison of continuous and categorical variables, respectively.

RESULTS:

Patients receiving nutritional supplemention with TGF-β2-enriched formula (groups I and II) experienced a significantly lower median number of diarrhea episodes compared to patients receiving nutritional supplementation with other products (group III), which was statistically significant (p<0.05). Also, number of patients experiencing grade 2 and grade 3 diarrhea was significantly lower in groups I and II compared to group III (p<0.05).

CONCLUSIONS:

Nutritional supplemention with TGF-β2-enriched formula offers amelioration of radiation-induced diarrhea for patients receiving pelvic RT. Since this is the first study assessing the use of nutritional supplementation with TGF-β2-enriched formula for patients undergoing pelvic RT, future prospective studies are needed to confirm the results.

• Authors: Selcuk Demiral, Murat Beyzadeoglu, Omer Sager, Ferrat Dincoglan, Bora Uysal, Hakan Gamsiz, Mustafa Akin, Turker Turker
• Journal: Tumori (Tumori) 2015 Sep-Oct Vol. 101 Issue 5 Pg. 474-7 ISSN: 2038-2529 [Electronic] United States
• PMID: 25983098 (Publication Type: Journal Article)

Chemical References

• Transforming Growth Factor beta2

Topics

• Adult
• Aged
• Diarrhea (drug therapy, etiology)
• Dietary Supplements
• Female
• Humans
• Intestinal Mucosa (radiation effects)
• Male
• Middle Aged
• Pelvic Neoplasms (radiotherapy)
• Radiotherapy (adverse effects)
• Retrospective Studies
• Transforming Growth Factor beta2 (therapeutic use)
• Treatment Outcome