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Anti-tumor activities of active ingredients in Compound Kushen Injection.

Abstract
Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.
AuthorsWei Wang, Rong-li You, Wen-jie Qin, Li-na Hai, Ming-jing Fang, Guo-hua Huang, Rui-xia Kang, Ming-hua Li, Yu-feng Qiao, Jian-wei Li, An-ping Li
JournalActa pharmacologica Sinica (Acta Pharmacol Sin) Vol. 36 Issue 6 Pg. 676-9 (Jun 2015) ISSN: 1745-7254 [Electronic] United States
PMID25982630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Quinolizines
  • oxymatrine
  • kushen
  • Matrines
Topics
  • Alkaloids (administration & dosage)
  • Animals
  • Antineoplastic Agents, Phytogenic (administration & dosage, analysis)
  • Drugs, Chinese Herbal (administration & dosage, analysis)
  • Humans
  • Injections
  • Medicine, Chinese Traditional (methods)
  • Neoplasms (drug therapy, metabolism, pathology)
  • Quinolizines (administration & dosage)
  • Treatment Outcome
  • Matrines

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