Abstract | BACKGROUND: PURPOSE: In this study, we aimed to explore the mutual transformation between polydatin and resveratrol in rats, and to compare the antioxidative effect of them in vivo. STUDY DESIGN: In this study, we analyzed the serum molar concentration of polydatin and resveratrol after oral administration in rats and evaluated the anti-oxidative stress effects of them using a mouse model. METHODS: Rats were orally administered polydatin or resveratrol and the concentration of them in serum were analyzed by high performance liquid chromatography (HPLC). Their antioxidative effect was compared in mice with oxidative stress cardiomyopathy induced by doxorubicin (DOX). RESULTS: CONCLUSION:
|
Authors | Hui-Lin Wang, Jian-Ping Gao, Yu-Liang Han, Xu Xu, Rong Wu, Yan Gao, Xiao-Hua Cui |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 22
Issue 5
Pg. 553-9
(May 15 2015)
ISSN: 1618-095X [Electronic] Germany |
PMID | 25981921
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier GmbH. All rights reserved. |
Chemical References |
- Antioxidants
- Glucosides
- Stilbenes
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione
- Resveratrol
- polydatin
|
Topics |
- Administration, Oral
- Animals
- Antioxidants
(pharmacology)
- Biotransformation
- Catalase
(blood)
- Chromatography, High Pressure Liquid
- Fallopia japonica
(chemistry)
- Glucosides
(blood, pharmacokinetics)
- Glutathione
(metabolism)
- Glutathione Peroxidase
(blood)
- Male
- Mice
- Myocardium
(metabolism)
- Oxidative Stress
(drug effects)
- Rats, Sprague-Dawley
- Resveratrol
- Rhizome
(chemistry)
- Stilbenes
(blood, pharmacokinetics)
- Superoxide Dismutase
(blood)
|