Abstract |
Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2-, IgG- cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.
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Authors | L Strzadala, I Rak, E Ziolo, M Paprocka, C Radzikowski, W Den Otter |
Journal | Cancer immunology, immunotherapy : CII
(Cancer Immunol Immunother)
Vol. 30
Issue 1
Pg. 51-6
( 1989)
ISSN: 0340-7004 [Print] Germany |
PMID | 2598176
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycosphingolipids
- Immunoglobulin G
- G(M1) Ganglioside
- asialo GM1 ganglioside
- Cyclophosphamide
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Topics |
- Animals
- Cyclophosphamide
(pharmacology)
- Female
- G(M1) Ganglioside
- Glycosphingolipids
(analysis)
- Immunoglobulin G
(immunology)
- Killer Cells, Natural
(immunology)
- Mice
- Neoplasm Metastasis
- Spleen
(immunology)
- T-Lymphocytes
(immunology)
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