Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity.

Abstract

Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2-, IgG- cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.

• Authors: L Strzadala, I Rak, E Ziolo, M Paprocka, C Radzikowski, W Den Otter
• Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 30 Issue 1 Pg. 51-6 ( 1989) ISSN: 0340-7004 [Print] Germany
• PMID: 2598176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycosphingolipids
• Immunoglobulin G
• G(M1) Ganglioside
• asialo GM1 ganglioside
• Cyclophosphamide

Topics

• Animals
• Cyclophosphamide (pharmacology)
• Female
• G(M1) Ganglioside
• Glycosphingolipids (analysis)
• Immunoglobulin G (immunology)
• Killer Cells, Natural (immunology)
• Mice
• Neoplasm Metastasis
• Spleen (immunology)
• T-Lymphocytes (immunology)