In-vivo iMap IVUS comparison of in-stent neointima and native coronary atherosclerosis.

Abstract

PURPOSE:

The purpose of this study was to compare plaque characteristics of native coronary atherosclerosis and in-stent neointima ten months after ST elevation myocardial infarction (STEMI) using iMap intravascular ultrasound (IVUS).

METHODS:

In 49 patients in-stent neointima and the coronary segment proximal to the stent were analyzed with iMap intravascular ultrasound (IVUS) ten months after primary PCI for STEMI.

RESULTS:

A higher percentage of necrotic tissue was observed in the proximal coronary segment compared to the in-stent neointima by iMap IVUS (25.5% ± 12.8% vs 12.3% ± 3.3%, p < 0.0001) ten months after STEMI. The proportion of fibrotic tissue in the proximal segment was lower (63.6% ± 14.8% vs 72.0% ± 5.7%, p = 0.002) and the proportion of the lipidic tissue was higher (8.8% ± 3.0% vs 5.9% ± 2.0%, p < 0.0001) than in-stent neointima.

CONCLUSIONS:

In patients ten months after STEMI, in-stent neointima contained a higher proportion of fibrotic tissue and lower proportion of necrotic and lipidic tissue compared the native atherosclerotic lesion.

• Authors: Karlis Trusinskis, Karlis Strenge, Dace Juhnevica, Andrejs Erglis
• Journal: Cardiovascular revascularization medicine : including molecular interventions (Cardiovasc Revasc Med) Vol. 16 Issue 4 Pg. 233-6 (Jun 2015) ISSN: 1878-0938 [Electronic] United States
• PMID: 25980925 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Coronary Angiography (methods)
• Coronary Artery Disease (diagnostic imaging)
• Female
• Humans
• Male
• Middle Aged
• Myocardial Infarction (diagnostic imaging)
• Neointima (diagnostic imaging)
• Percutaneous Coronary Intervention
• Plaque, Atherosclerotic (diagnostic imaging, pathology)
• Stents
• Ultrasonography, Interventional (methods)