Abstract | OBJECTIVE: To explore the anti- obesity effects and the mechanism of action of Monascus pilosus(M. pilosus)-fermented black soybean (MFBS) extracts (MFBSE) and MFBS powders (MFBSP) in adipocytes and high-fat diet (HFD)-induced obese mice, respectively. METHODS: Black soybean was fermented with M. pilosus, and the main constituents in MFBS were analyzed by HPLC analysis. In vitro, MFBSE were examined for anti-adipogenic effects using Oil-Red O staining. In vivo, mice were fed a normal-fat diet ( NFD) control, HFD control or HFD containing 1 g/kg MFBSP for 12 weeks, and then body weight gain and tissues weight measured. Real-time PCR and western blot assay were used to determine the mechanism of anti-adipogenic effects. RESULTS: CONCLUSIONS: These results suggest that the anti- obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFD-induced obese mice.
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Authors | Young-Sil Lee, Bong-Keun Choi, Hae Jin Lee, Dong-Ryung Lee, Jinhua Cheng, Won-Keun Lee, Seung Hwan Yang, Joo-Won Suh |
Journal | Asian Pacific journal of tropical medicine
(Asian Pac J Trop Med)
Vol. 8
Issue 4
Pg. 276-82
(Apr 2015)
ISSN: 2352-4146 [Electronic] India |
PMID | 25975498
(Publication Type: Journal Article)
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