Abstract | BACKGROUND: Dietary silicon has been positively linked with vascular health and protection against atherosclerotic plaque formation, but the mechanism of action is unclear. OBJECTIVES: We investigated the effect of dietary silicon on 1) serum and aorta silicon concentrations, 2) the development of aortic lesions and serum lipid concentrations, and 3) the structural and biomechanic properties of the aorta. METHODS: RESULTS: The serum silicon concentration in the -Si group was significantly lower than in the +Si-feed (by up to 78%; P < 0.003) and the +Si-water (by up to 84%; P < 0.006) groups. The aorta silicon concentration was also lower in the -Si group than in the +Si-feed group (by 65%; P = 0.025), but not compared with the +Si-water group. There were no differences in serum and aorta silicon concentrations between the silicon-replete groups. Body weights, tissue wet weights at necropsy, and structural, biomechanic, and morphologic properties of the aorta were not affected by dietary silicon; nor were the development of fatty lesions and serum lipid concentrations. CONCLUSIONS:
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Authors | Ravin Jugdaohsingh, Katharina Kessler, Barbara Messner, Martin Stoiber, Liliana D Pedro, Heinrich Schima, Günther Laufer, Jonathan J Powell, David Bernhard |
Journal | The Journal of nutrition
(J Nutr)
Vol. 145
Issue 7
Pg. 1498-506
(Jul 2015)
ISSN: 1541-6100 [Electronic] United States |
PMID | 25972522
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Silicon
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Topics |
- Animals
- Aorta
(drug effects, metabolism)
- Apolipoproteins E
(genetics)
- Atherosclerosis
(blood, drug therapy)
- Body Weight
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diet
- Diet, High-Fat
(adverse effects)
- Dietary Supplements
- Disease Models, Animal
- Endothelium, Vascular
(drug effects, metabolism)
- Female
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Plaque, Atherosclerotic
(blood, prevention & control)
- Silicon
(administration & dosage, blood, deficiency)
- Triglycerides
(blood)
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