Interferon-alpha caused reversible parkinsonism.

Abstract

Interferon has been used to treat chronic viral hepatitis and several malignancies. However, it may cause various neuropsychiatric adverse effects including parkinsonism. We report a rare case of interferon alpha-2a therapy-related parkinsonism in a 67-year-old man with metastatic papillary renal cell carcinoma and our experience of using Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) as a tool for evaluation of parkinsonism. Physicians should be alert to the possibility of interferon alpha-2a-related parkinsonism.

• Authors: Chieh-Sheng Lu, Wei-Yau Kao, Jiann-Chyun Lin, Ping-Ying Chang
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2015 May-Jun Vol. 38 Issue 3 Pg. 119-20 ISSN: 1537-162X [Electronic] United States
• PMID: 25970283 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunologic Factors
• Interferon alpha-2
• Interferon-alpha
• Organotechnetium Compounds
• Recombinant Proteins
• Tropanes
• technetium Tc 99m TRODAT-1

Topics

• Aged
• Brain (diagnostic imaging, pathology)
• Diagnosis, Differential
• Humans
• Immunologic Factors (administration & dosage, adverse effects)
• Interferon alpha-2
• Interferon-alpha (administration & dosage, adverse effects)
• Male
• Organotechnetium Compounds
• Parkinsonian Disorders (chemically induced, diagnosis, diagnostic imaging, pathology)
• Recombinant Proteins (administration & dosage, adverse effects)
• Tomography, Emission-Computed, Single-Photon (methods)
• Tropanes