Abstract |
Vitamin A deficiency (A(-)) remains a public health concern in developing countries and is associated with increased susceptibility to infection. Citrobacter rodentium was used to model human Escherichia coli infections. A(-) mice developed a severe and lethal (40%) infection. Vitamin A-sufficient (A(+)) mice survived and cleared the infection by day 25. Retinoic acid treatment of A(-) mice at the peak of the infection eliminated C. rodentium within 16 days. Inflammation levels were not different between A(+) and A(-) mouse colons, although the A(-) mice were still infected at day 37. Increased mortality of A(-) mice was not due to systemic cytokine production, an inability to clear systemic C. rodentium, or increased pathogenicity. Instead, A(-) mice developed a severe gut infection with most of the A(-) mice surviving and resolving inflammation but not eliminating the infection. Improvements in vitamin A status might decrease susceptibility to enteric pathogens and prevent potential carriers from spreading infection to susceptible populations.
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Authors | Kaitlin L McDaniel, Katherine H Restori, Jeffery W Dodds, Mary J Kennett, A Catharine Ross, Margherita T Cantorna |
Journal | Infection and immunity
(Infect Immun)
Vol. 83
Issue 7
Pg. 2984-91
(Jul 2015)
ISSN: 1098-5522 [Electronic] United States |
PMID | 25964475
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015, American Society for Microbiology. All Rights Reserved. |
Topics |
- Animals
- Asymptomatic Diseases
- Citrobacter rodentium
(isolation & purification)
- Colon
(microbiology, pathology)
- Disease Models, Animal
- Disease Susceptibility
- Enterobacteriaceae Infections
(pathology)
- Mice, Inbred C57BL
- Survival Analysis
- Vitamin A Deficiency
(complications)
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