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Vitamin A-Deficient Hosts Become Nonsymptomatic Reservoirs of Escherichia coli-Like Enteric Infections.

Abstract
Vitamin A deficiency (A(-)) remains a public health concern in developing countries and is associated with increased susceptibility to infection. Citrobacter rodentium was used to model human Escherichia coli infections. A(-) mice developed a severe and lethal (40%) infection. Vitamin A-sufficient (A(+)) mice survived and cleared the infection by day 25. Retinoic acid treatment of A(-) mice at the peak of the infection eliminated C. rodentium within 16 days. Inflammation levels were not different between A(+) and A(-) mouse colons, although the A(-) mice were still infected at day 37. Increased mortality of A(-) mice was not due to systemic cytokine production, an inability to clear systemic C. rodentium, or increased pathogenicity. Instead, A(-) mice developed a severe gut infection with most of the A(-) mice surviving and resolving inflammation but not eliminating the infection. Improvements in vitamin A status might decrease susceptibility to enteric pathogens and prevent potential carriers from spreading infection to susceptible populations.
AuthorsKaitlin L McDaniel, Katherine H Restori, Jeffery W Dodds, Mary J Kennett, A Catharine Ross, Margherita T Cantorna
JournalInfection and immunity (Infect Immun) Vol. 83 Issue 7 Pg. 2984-91 (Jul 2015) ISSN: 1098-5522 [Electronic] United States
PMID25964475 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Topics
  • Animals
  • Asymptomatic Diseases
  • Citrobacter rodentium (isolation & purification)
  • Colon (microbiology, pathology)
  • Disease Models, Animal
  • Disease Susceptibility
  • Enterobacteriaceae Infections (pathology)
  • Mice, Inbred C57BL
  • Survival Analysis
  • Vitamin A Deficiency (complications)

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