Abstract | BACKGROUND: MATERIAL AND METHODS: ME and ACLY expression was analyzed in 258 NSCLC in correlation with clinico-pathological parameters including patient's survival. RESULTS: Though, overall expression of both enzymes correlated positively, ACLY was associated with local tumor stage, whereas ME correlated with occurrence of mediastinal lymph node metastases. Young patients overexpressing ACLY and/or ME had a significantly longer overall survival. This proved to be an independent prognostic factor. This contrasts older NSCLC patients, in whom overexpression of ACLY and/or ME appears to predict the opposite. CONCLUSION: In NSCLC, ME and ACLY show different enzyme expressions relating to local and mediastinal spread. Most important, we detected an inverse prognostic impact of ACLY and/or ME overexpression in young and elderly patients. It can therefore be expected, that treatment of NSCLC especially, if targeting metabolic pathways, requires different strategies in different age groups.
|
Authors | Agnes Csanadi, Claudia Kayser, Marcel Donauer, Vera Gumpp, Konrad Aumann, Justyna Rawluk, Antje Prasse, Axel zur Hausen, Sebastian Wiesemann, Martin Werner, Gian Kayser |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 5
Pg. e0126357
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25962060
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Malate Dehydrogenase
- ATP Citrate (pro-S)-Lyase
|
Topics |
- ATP Citrate (pro-S)-Lyase
(metabolism)
- Aged
- Carcinoma, Non-Small-Cell Lung
(enzymology, pathology)
- Humans
- Immunohistochemistry
- Malate Dehydrogenase
(metabolism)
- Middle Aged
- Prognosis
|