Abstract | BACKGROUND: DESIGN AND METHODS: RESULTS: DRSP and P elicited a similar significant inhibition of proliferation of HMECs in combination with GFs. LNG and MPA had no effect. DRSP, P, MPA and LNG were able to significantly inhibit the proliferation of HCC1500 and T-47D cells in combination with E2. No significant difference between the progestogens was observed in HCC1500 cells, whereas in T-47D cells both DRSP and P were significantly more effective at 10 μM than LNG and MPA. CONCLUSION: Because different results were found in the same experimental model, it appears that progestogens do not react similarly on the proliferation of human breast epithelial cells. However, for assessment of breast cancer risk different models should be used, because various mechanism(s) might be involved. It is also important to use benign as well as cancerous cell lines. The choice of progestogen could be of significance in terms of breast cancer risk under hormone therapy.
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Authors | Harald Seeger, Xiangjan Ruan, Hans Neubauer, Alfred O Mueck |
Journal | Hormone molecular biology and clinical investigation
(Horm Mol Biol Clin Investig)
Vol. 6
Issue 2
Pg. 211-4
(May 01 2011)
ISSN: 1868-1883 [Print] Germany |
PMID | 25961257
(Publication Type: Journal Article)
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