Profile of conbercept in the treatment of neovascular age-related macular degeneration.

Abstract

In developed countries, age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over the age of 65 years. Vascular endothelial growth factor (VEGF) plays a vital role in the formation of neovascular AMD. VEGF regulates angiogenesis, enhances vascular permeability, and drives the formation of choroidal neovascularization. As a result of the introduction of anti-VEGF drugs, the incidence of blindness from neovascular AMD has greatly reduced. Anti-VEGF drugs are used as a first-line treatment for neovascular AMD. The most recent anti-VEGF drug is conbercept, also named KH902, which was approved for the treatment of neovascular AMD by the China Food and Drug Administration in December 2013. In this review, recent clinical information regarding the use of conbercept to treat neovascular AMD is summarized. Conbercept is a soluble receptor decoy that blocks all isoforms of VEGF-A, VEGF-B, VEGF-C, and PlGF, which has a high binding affinity to VEGF and a long half-life in vitreous. Preclinical studies have demonstrated its anti-angiogenesis activity in both ocular neovascular disease models and tumor models. Clinical trials of conbercept have shown its superior efficacy and safety. Patients respond well even with 3-month treatment intervals following loading doses once a month for 3 months. The potential therapeutic effect of conbercept on the treatment of polypoidal choroidal vasculopathy, a special type of neovascular AMD, is also promising. In summary, conbercept is a new treatment option for ophthalmologists and their patients and may help address the limitations of current anti-VEGF drugs.

• Authors: Xinmin Lu, Xiaodong Sun
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 9 Pg. 2311-20 ( 2015) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 25960634 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Angiogenesis Inhibitors
• Recombinant Fusion Proteins
• Vascular Endothelial Growth Factor A
• KH902 fusion protein

Topics

• Aged
• Aged, 80 and over
• Aging (pathology)
• Angiogenesis Inhibitors (adverse effects, pharmacokinetics, therapeutic use)
• Animals
• Choroidal Neovascularization (drug therapy)
• Humans
• Macular Degeneration (drug therapy)
• Middle Aged
• Recombinant Fusion Proteins (adverse effects, pharmacokinetics, therapeutic use)
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)