[Vitamin D deficiency prediction by patient questionnaire and secondary hyperparathyroidism in a cohort of 526 healthy subjects in their fifties].

Abstract

INTRODUCTION:

Can vitamin D deficiency be predicted by patient questionnaire? Does it lead to secondary hyperparathyroidism that may cause excessive bone resorption? We studied non-osteoporotic subjects in their fifties, in whom vitamin D levels are often tested.

PATIENTS AND METHODS:

Patients hospitalised for degenerative osteoarthritis or consulting for assessment of menopause, without renal failure and not treated with vitamin D, completed a questionnaire on sun exposure and underwent measurement of serum calcium, creatinine, 25OH vitamin D, PTH and CTX.

RESULTS:

Five hundred and twenty-six subjects, mean age 54.6 years (71% women), were investigated throughout the year. 25OH vitamin D levels were correlated with sun exposure and varied according to the month of the year, unlike PTH and CTX levels. From November to May, over 90% of subjects had 25OH vitamin D levels<30ng/mL. Of the subjects who did not expose their face, arms and legs to the sun for at least 20min/day, 94% had 25OH vitamin D levels<30ng/mL. PTH levels were negatively correlated with those of 25OH vitamin D. Serum CTX levels were not correlated with PTH or 25OH vitamin D. Only 13% of subjects presented with secondary hyperparathyroidism, characterised by serum calcium<2.55mmol/L and PTH>65pg/mL, associated with increased CTX levels.

CONCLUSION:

Vitamin D deficiency can be predicted by patient questionnaire. It very rarely leads to secondary hyperparathyroidism.

• Authors: Michel Laroche, Delphine Nigon, Isabelle Gennero, Slim Lassoued, Jean-Michel Pouilles, Florence Trémolières, Marion Vallet, Ivan Tack
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) 2015 Jul-Aug Vol. 44 Issue 7-8 Pg. e283-90 ISSN: 2213-0276 [Electronic] France
• Vernacular Title: Le déficit en vitamine D, très fréquent, n'entraîne qu'exceptionnellement une hyperparathyroïdie secondaire chez des sujets sains de la cinquantaine: cohorte de 526 sujets.
• PMID: 25960439 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2015. Published by Elsevier Masson SAS.

Chemical References

• Collagen Type I
• Parathyroid Hormone
• Peptides
• collagen type I trimeric cross-linked peptide
• Vitamin D
• Calcium

Topics

• Calcium (blood)
• Cohort Studies
• Collagen Type I (blood)
• Female
• Healthy Volunteers (statistics & numerical data)
• Humans
• Hyperparathyroidism, Secondary (diagnosis, etiology)
• Male
• Middle Aged
• Parathyroid Hormone (blood)
• Peptides (blood)
• Prognosis
• Surveys and Questionnaires
• Vitamin D (blood)
• Vitamin D Deficiency (complications, diagnosis)