Abstract | BACKGROUND: METHODS: This study was a prospective, randomized, open-label study. Twenty-six Japanese patients (age >30 years) with diabetic nephropathy and arteriosclerosis obliterans were randomly assigned to the BPS group (n=13), which received the combination of an RAS inhibitor and BPS (120 μg/day) therapy, or the control group (n=13), which received only an RAS inhibitor. Patients were followed up for 1 year. The primary endpoint was the effect of BPS on renal function. RESULTS: In the control group, serum creatinine (1.64±0.87 to 2.34±1.53 mg/dL, p<0.001), 1/ creatinine (0.82±0.47 to 0.65±0.47, p=0.003) cystatin C (1.77±0.61 to 2.18±0.86 mg/L, p<0.001), and the estimated glomerular filtration rate (43.9±26.1 to 34.0±24.6 mL/min/1.73 m(2), p=0.004) were significantly worsened 48 weeks after the start of treatment. Conversely, in the BPS group, serum creatinine (1.71±0.75 to 1.66±0.81 mg/dL, p=0.850), 1/ creatinine (0.66±0.19 to 0.71±0.25, p=0.577), cystatin C (1.79±0.55 to 1.80±0.57 mg/L, p=0.999), and the estimated glomerular filtration rate (35.8±10.8 to 38.7±14.4 mL/min/1.73 m(2), p=0.613) were unchanged. CONCLUSIONS: Combination treatment with BPS and an RAS inhibitor prevented the progression of diabetic nephropathy. These observations should be confirmed in large-scale studies with long-term follow-up.
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Authors | Ayaka Shima, Masaaki Miyamoto, Yoshiaki Kubota, Gen Takagi, Wataru Shimizu |
Journal | Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
(J Nippon Med Sch)
Vol. 82
Issue 2
Pg. 84-91
( 2015)
ISSN: 1347-3409 [Electronic] Japan |
PMID | 25959199
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- CST3 protein, human
- Cystatin C
- beraprost
- Creatinine
- Epoprostenol
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Topics |
- Aged
- Arteriosclerosis Obliterans
(diagnosis, drug therapy, physiopathology)
- Biomarkers
(blood)
- Creatinine
(blood)
- Cystatin C
(blood)
- Diabetic Nephropathies
(diagnosis, drug therapy, physiopathology)
- Disease Progression
- Epoprostenol
(analogs & derivatives, therapeutic use)
- Female
- Glomerular Filtration Rate
(drug effects)
- Humans
- Japan
- Kidney Failure, Chronic
(physiopathology, prevention & control)
- Male
- Middle Aged
- Prospective Studies
- Renin-Angiotensin System
(drug effects)
- Time Factors
- Treatment Outcome
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