Abstract | STUDY OBJECTIVE: DESIGN: Prospective study (Canadian Task Force classification II-1). SETTING: University-affiliated hospital. PATIENTS: Ninety-one women with large myomas (≥10 cm) or more than 2 myomas ≥ 5 cm underwent LM between July 2011 and March 2014. INTERVENTIONS: Forty patients underwent LM after GnRHa use (group A) and 51 underwent LM only (group B). GnRHa was used for 3 doses every 4 weeks before LM in group A. MEASUREMENTS AND MAIN RESULTS: Group A had a significantly smaller maximum diameter of the largest myoma than group B (8.5 ± 2.1 vs 10.7 ± 2.4, p < .001) and fewer patients with myomas larger than 10 cm after GnRHa administration (33% vs 67%, p = .001). In group A, there was a decrease in 2 or more myomas ≥ 5 cm (20% vs 50%) after GnRHa use. Group A also had significantly smaller mean myoma weight (448 vs 567 g, p = .045) and significantly shorter mean operative time (129 ± 30 vs 152 ± 34 minutes, p = .001). Most patients in group A (40%) had an operative time < 119 minutes, whereas most patients in group B (37%) had an operative time between 150 and 179 minutes. Group A also had less intraoperative blood loss (84 ± 53 vs 137 ± 166 mL, p < .001), drop in hemoglobin (1.5 ± 0.8 vs 3.0 ± 1.7 g/dl, p < .001), excessive bleeding (5% vs 33%, p = .001), postoperative hematoma (2.5% vs 9.8%, p = .168), and blood transfusion (7.5% vs 35%, p = .001). CONCLUSION:
|
Authors | Wen-Chun Chang, Ling-Hui Chu, Pei-Shen Huang, Su-Cheng Huang, Bor-Ching Sheu |
Journal | Journal of minimally invasive gynecology
(J Minim Invasive Gynecol)
2015 Sep-Oct
Vol. 22
Issue 6
Pg. 992-6
ISSN: 1553-4669 [Electronic] United States |
PMID | 25958038
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents, Hormonal
- Gonadotropin-Releasing Hormone
- Leuprolide
|
Topics |
- Adult
- Aged
- Antineoplastic Agents, Hormonal
(administration & dosage)
- Blood Loss, Surgical
(statistics & numerical data)
- Blood Transfusion
(statistics & numerical data)
- Female
- Gonadotropin-Releasing Hormone
(analogs & derivatives)
- Humans
- Laparoscopy
(adverse effects, methods)
- Leiomyoma
(surgery)
- Leuprolide
(administration & dosage)
- Middle Aged
- Operative Time
- Postoperative Hemorrhage
(prevention & control)
- Prospective Studies
- Treatment Outcome
- Uterine Myomectomy
(methods)
- Uterine Neoplasms
(surgery)
|