Participation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumors.

Abstract

OBJECTIVES:

To evaluate the expression of hMLH1, p63, and MDM2 in Gorlin syndrome-associated keratocystic odontogenic tumors (SKOTs) and nonsyndromic keratocystic odontogenic tumors (NSKOTs).

STUDY DESIGN:

Seventeen primary NSKOTs, 17 SKOTs, and 8 recurrent NSKOTs were analyzed by using immunohistochemistry.

RESULTS:

No significant differences in the hMLH1, p63, or MDM2 labeling indices were observed between groups (P = .398; P = .232; P = .426, respectively). Higher hMLH1 immunoexpression was found in the basal layer of primary NSKOTs. Most KOTs exhibited p63 immunoexpression in the upper layers of the epithelium. MDM2 immunoexpression was observed in the upper epithelial layers of SKOTs and recurrent NSKOTs.

CONCLUSION:

It was not possible to correlate the immunoexpression of hMLH1, p63, and MDM2 in SKOTs and primary and recurrent NSKOTs, suggesting that these proteins exert independent effects on the development of these groups of tumors.

• Authors: Bárbara Vanessa de Brito Monteiro, Roberta Barroso Cavalcante, Renato Luiz Maia Nogueira, Márcia Cristina da Costa Miguel, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas da Silveira
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 120 Issue 1 Pg. 52-7 (Jul 2015) ISSN: 2212-4411 [Electronic] United States
• PMID: 25957541 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• MLH1 protein, human
• Nuclear Proteins
• TP63 protein, human
• Transcription Factors
• Tumor Suppressor Proteins
• MDM2 protein, human
• Proto-Oncogene Proteins c-mdm2
• MutL Protein Homolog 1

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Basal Cell Nevus Syndrome (metabolism, pathology)
• Humans
• Immunoenzyme Techniques
• MutL Protein Homolog 1
• Nuclear Proteins (metabolism)
• Odontogenic Tumors (metabolism, pathology)
• Proto-Oncogene Proteins c-mdm2 (metabolism)
• Transcription Factors (metabolism)
• Tumor Suppressor Proteins (metabolism)