Abstract |
Aerosolized tobramycin was given to a 68-year-old man with resistant Pseudomonas aeruginosa pneumonitis at a dose of 100 mg every 8 h via a tracheostomy, after the patient failed to respond adequately to parenteral aminoglycoside and ticarcillin therapy. Minimum inhibitory concentration and minimum bactericidal concentration for tobramycin and gentamicin were 16 micrograms/ml and greater than 16 micrograms/ml, which necessitated aerosol administration. Tracheal concentrations 15 min and 4 h after a dose were 1,560 and 930 micrograms/ml. The patient responded and eventually was discharged from the hospital. Thus, monotherapy with an aerosolized aminoglycoside may be effective in some patients with resistant Pseudomonas aeruginosa pneumonitis.
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Authors | C Y McCall, W J Spruill, W E Wade |
Journal | Therapeutic drug monitoring
(Ther Drug Monit)
Vol. 11
Issue 6
Pg. 692-5
(Nov 1989)
ISSN: 0163-4356 [Print] United States |
PMID | 2595751
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aerosols
- Aged
- Humans
- Male
- Pneumonia
(drug therapy, microbiology)
- Pseudomonas Infections
(drug therapy, microbiology)
- Tobramycin
(administration & dosage, therapeutic use)
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